High-throughput Unmasking of Biological Interactomes with Binding Landscape Emulators (HUBBLE)

In plain English

The Defense Advanced Research Projects Agency (DARPA) seeks research proposals for HUBBLE, a computer-based tool to map all protein-protein interactions, aimed at finding diagnostic and treatment targets such as for traumatic brain injury. Amendment 1 updates an attachment and some sections. Details are in the attachments.

Agency: Dept Of Defense · Defense Advanced Research Projects Agency (Darpa)

Notice type: Solicitation

Set-aside: No set-aside (open to all)

NAICS: 541714

Place of performance: Not listed

Posted: Oct 28, 2026

Response due: Nov 5, 2026

Solicitation number: DARPA-PA-27-01

Open on SAM.gov

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Description

UPDATE: The purpose of Amendment 1 to DARPA-PA-27-01, the HUBBLE Program Announcement (PA), is to update Attachment B and the verbiage in Section 4.1.2 and Section 7.8 of the Program Announcement. The Defense Advanced Research Projects Agency (DARPA) is soliciting proposals to develop an in-silico capability for mapping all protein-protein interactions. Utility of this capability will be demonstrated in identifying novel diagnostic and therapeutic targets within the interaction space underlying including traumatic brain injury.

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